Protein Purification
Genscript Corporation CD96/TACTILE C110S His Hum
The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells and recent studies suggest both play important inhibitory roles in immune function CD96 has been shown to modulate immune cell activity in mice with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor CD226 offers unique strategies for immuno-oncology drug development
Invent Biotechnologies Inc Minute™ High-Efficiency Exosome Precipitation Reagent - Non-PEG (20 ml)
Exosomes are vesicles secreted by cells. They are present in a variety of body fluids such as serum, ascites, spinal cord fluid, urine, and saliva. Cultured cells also secrete significant number of exosomes. The size distribution of exosome is ranging from 30-120 nm. The biological function of exosomes is believed to serve as intercellular messengers. Filtration and ultracentrifugation are classical ways of isolating and enriching exosomes. This is a tedious process and requires special equipment. Another common way for enrichment of exosome is through precipitation. Currently major commercial kits are PEG-based. EI-027 is designed to precipitate total exosomes from biofluids using a high efficacy, non-PEG based reagent for exosome precipitation. This kit is suitable for routine biofluid samples using the same reagent and similar protocol. More information: https://inventbiotech.com/products/minute%E2%84%A2-hi-efficiency-exosome-precipitation-reagent?_pos=1&_sid=c6bc0e161&_ss=r
Invent Biotechnologies Inc Minute™ Detergent-Free Nuclear Matrix Protein Extraction Kit (For Mammalian Cultured Cells/Tissues) - Spin Column-Based (20 Preps)
Nucleoplasm, also referred to as karyoplasm/nucleus sap, consists of chromosomes, nucleolus and nuclear matrix. Nucleoplasm plays a central role in genetic information flow and regulation of gene expression. Nuclear protein isolation has traditionally been accomplished by extraction protocol using detergent-containing buffers, which is effective in extracting total nuclear proteins but unable to separate membrane-bound proteins and water-soluble matrix proteins. The detergent-free nuclear matrix protein extraction kit is designed to separate cellular protein into three fractions: cytosolic, nuclear matrix and water-insoluble fractions (mainly envelope and nucleic acid-associated proteins) using a patented spin-column-based technology. The buffers used are detergent and EDTA-free. The proteins extracted are in their native state and can be used in many downstream applications such as gel retardation, transcription factor analysis, apoptosis and protein trafficking studies.
Medchemexpress LLC BID Mouse His-GST 10ug
BID Protein a pro-apoptotic member of the Bcl-2 family is initially discovered through binding to both pro-apoptotic Bax and anti-apoptotic Bcl-2 BID is activated in the BCL-2-regulated or mitochondrial apoptosis pathway and acts as a switch between the extrinsic and intrinsic cell death pathways BID is susceptible to proteolytic cleavage by caspases calpains Granzyme B and cathepsins BID Protein Mouse (His-GST) is the recombinant mouse-derived BID protein expressed by E coli with N-His N-GST labeled tag
Bioworld PROTEOSPIN TOTAL PROTEIN DE
PROTEOSPIN TOTAL PROTEIN DETERGENT CLEANUP KIT: For the rapid concentration and clean-up of protein samples Concentrate protein samples and remove detergents at the same time; Rapid and convenient spin-column protocol; Effectively remov...
Cayman Chemical BCATc InhIbItr 2 50mg
A sulfonyl hydrazide that inhibits BCATc (IC50s = 0.81 and 0.2 µM in human and rat, respectively) with 15-fold selectivity over BCATm; blocks calcium influx into neurons (IC50 = 4.8 µM) following inhibition of glutamate uptake and demonstrates neuroprotective efficacy in vivo
Cayman Chemical BCATc InhIbItr 2 5mg
A sulfonyl hydrazide that inhibits BCATc (IC50s = 0.81 and 0.2 µM in human and rat, respectively) with 15-fold selectivity over BCATm; blocks calcium influx into neurons (IC50 = 4.8 µM) following inhibition of glutamate uptake and demonstrates neuroprotective efficacy in vivo
Genscript Corporation 4-1BB/TNFRSF9Biotin His A
4-1BB is also known as CD137 is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily CD137 can be expressed by activated T cells but to a larger extent on CD8 than on CD4 T cells In addition CD137 expression is found on dendritic cells B cells follicular dendritic cells natural killer cells granulocytes and cells of blood vessel walls at sites of inflammation
Cayman Chemical h-e5NT InhIbItr 5C 1mg
An inhibitor of ecto-5'-nucleotidase (IC50s = 0.37 and 1.66 µM for the human and rat enzymes, respectively); inhibits ENPP1, ENPP3, and TNAP (IC50s = 1.12, 1.37, and 1.48 µM, respectively, for the human enzymes)
Cayman Chemical NFATc1 InhIbItr A04 5mg
An NFATc1 inhibitor; inhibits RANKL-induced nuclear translocation of NFATc1 in RAW 264.7 cells at 1.5 or 2 µM; reduces RANKL-induced differentiation of RAW 264.7 cells into osteoclasts (IC50 = 1.57 µM)
Cayman Chemical IRAK4 InhIbItr 28 25mg
An IRAK4 inhibitor (IC50 = 0.005 µM); selective for IRAK4 over IRAK1, Clk1, and Clk3 (IC50s = 0.023, 0.05, and >1 µM, respectively) but does inhibit Clk2, Clk4, and haspin (IC50s = 0.005, 0.008, and 0.004 µM, respectively); inhibits IκBα phosphorylation in OCI-LY10 DLBCL cells from 0.12-3.3 µM; reduces tumor volume in an OCI-LY10 mouse xenograft model at 12.5 mg/kg
Hampton Research STOCKOPTIONS BICINE #04 PH 7.7
HR2-101-04/StockOptions Bicine #04 pH 7.7, 185 ml. Please note items from this supplier are non-returnable.
Hampton Research SOL & STABILITY #60 (E12)
HR2-072-60/Solubility & Stability #60 (E12), 1.0 ml - 500 mM Ammonium chloride. Please note items from this supplier are non-returnable.
Hampton Research SOL & STABILITY #59 (E11)
HR2-072-59/Solubility & Stability #59 (E11), 1.0 ml - 500 mM Ammonium sulfate. Please note items from this supplier are non-returnable.